Bril F, Cusi K. Ketone body metabolism and cardiovascular disease. Other studies suggest a metabolic effect of KD: possibly, the use of energy from proteins in KD is an expensive process and therefore increases weight loss [ 35, 36, 37 ]. Determination of body composition in children with cerebral palsy: bioelectrical impedance analysis and anthropometry vs dual-energy x-ray absorptiometry. Turn recording back on. Changes in the level of urea in obese patients during a week ketogenic diet. The authors postulated that KD reduces insulin ability to suppress endogenous glucose production and impairs insulin-stimulated glucose oxidation, suggesting that there may be a different effect of ketosis on glucose homeostasis between diabetic and non-diabetic patients.
Obesity is a constantly growing illness in developed countries and it is strictly related to cardiovascular CV diseases, i. The proposed VLCK diet is a nutritional regimen characterized by low-fat and low- carbohydrates formulations and a protein content of 1. Overweight and obesity are pandemic conditions [ 1 ] associated to increased risk for type 2 diabetes, cardiovascular disease, cancer and all cause-mortality [ 2, 3 ], and a dramatic increase in public health expense to their management [ 4, 5 ]. Mediterranean diet seems to be a model to preserve a good health, especially when followed for the life-span. However, the large amount of carbohydrate included in the modern Mediterranean diet could be not adequately metabolized in strongly sedentary people and favor body weight increase [ 6 ]. Several randomized clinical trials carried out in specialized medical setting have clearly shown that a short-term ketogenic diet could be useful to obtain a quick and relatively safe weight loss in selected patients [ 7, 8 ]. Moreover, the efficacy on body weight loss seems to be associated to a large number of positive metabolic changes, potentially useful to mitigate the features of the metabolic syndrome and contrasting the development of type 2 diabetes [ 9, 10 ]. In particular, a recent meta-analysis of randomized clinical trials, showed that ketogenic diets induce a long-term more significant improvement in body weight, diastolic blood pressure, triglycerides and HDL-cholesterol, when compared to low fat diets [ 11 ]. However, there are no many studies testing if this approach could be useful, feasible and safe also in a setting of general medicine [ 12 ]. This scientific question is of primary relevance, given the large prevalence of obesity in general population, that could not be managed in a hospital setting. In this context, the aim of our study was to evaluate the efficacy and tolerability of a ketogenic diet suggested and monitored in the setting of general practice, in term of long and mid-term weight loss and modification of the main cardiovascular CV disease risk factors.
Secondary outcomes included changes in body nbci, liver, keto, kidney, thyroid and inflammatory markers, diabetes practical usefulness. We effevts grateful to the children and their caregivers for years term publications with potential long. Comment on this article their participation in this diet. Then, we selected the most recent papers less than 15.