The snippet could not be located in the article text. Int J Mol Sci. The gene-specific positive and negative effects of the HF diet indicate a likely diversity in the underlying regulatory processes and the involvement of specific molecular mechanisms. Allen Endowed Chair. Cancer Metastasis Rev. Significantly, the findings in our system were consistent with observations in primate and mouse models, which also pointed toward a repressive effect of lipid exposure and insulin on GHRHR expression [ 6, 7 ]. We also determined whether the expression of this central regulator of anterior pituitary transcription POU1F1 is affected by the HF diet.
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The emerging obesity epidemic and its co-morbid conditions, such as colorectal cancer, pose a great challenge to global health and healthcare cost. This reinforces the urgent need to elucidate the underlying mechanisms contributing to the promotion of colon cancer in individuals with obesity. Extensive epidemiological studies have demonstrated a consistent and compelling association between obesity and the risk of cancer development and progression. Furthermore, our previous studies demonstrate that obesity induced by high-fat diet results in the expansion of the colonic stem cell pool during cancer initiation. However, the mechanistic link between obesity and the initiation and development of colon cancer remains elusive. Since the biophysical properties of the plasma membrane contribute to cellular signaling, we hypothesized that obesity alters colonic stem cell homeostasis via modulation of the biophysical properties of the plasma membrane, subsequently altering cell signaling events. Our studies utilized complementary in vivo and ex vivo mouse models including colonic organoids. Effects of nanoclustering on the activation status of downstream signaling targets was subsequently assessed.
|Diet high chapkin fat opinion you commit error||Since the biophysical properties of the plasma membrane contribute to cellular signaling, we hypothesized that obesity alters colonic stem cell homeostasis via modulation of the biophysical properties of the plasma membrane, subsequently altering cell signaling events. Keywords: obesity, n-3 PUFA, hypothalamic-pituitary axis, growth hormone. J Biol Chem , , — B Effects of high fat diet alone or supplemented with fish oil on transcript levels of selected genes expressed in the pituitary and C hypothalamus.|
|Happens chapkin diet high fat what result Willingly accept||Although previous research using whole body AhR knockout mice has revealed an increased incidence of colon and cecal tumors, the unique role of AhR activity in intestinal epithelial cells IECs and modifying effects of fat content in the diet at different stages of sporadic CRC development are yet to be elucidated. Proteomics Data. Mol Nutr Food Res.|