NCGS is included in the spectrum of gluten-related disorders. The pathogenesis of NCGS is not yet well understood, but the activation of the innate immune system, the direct cytotoxic effects of gluten and probably other wheat components, are implicated. ATIs are potent activators of the innate immune system. For these reasons, NCGS is a controversial clinical condition  and some authors still question it. NCGS is the most common syndrome of gluten-related disorders   with prevalence rates between 0. Reported symptoms of NCGS are similar to those of celiac disease,   with most patients reporting both gastrointestinal and non-gastrointestinal symptoms. Wheat allergy has a fast onset from minutes to hours after the consumption of food containing wheat and can be anaphylaxic. Gastrointestinal symptoms may include any of the following: abdominal pain, bloating, bowel habit abnormalities either diarrhea or constipation,   nausea, aerophagia, flatulence, gastroesophageal reflux disease, and aphthous stomatitis. NCGS can cause a wide range of extraintestinal symptoms, which can be the only manifestation of NCGS in absence of gastrointestinal symptoms.
Gluten-related disorders is the term for the diseases triggered by gluten, including celiac disease CD, non-celiac gluten sensitivity NCGS, gluten ataxia, dermatitis herpetiformis DH and wheat allergy. Gluten is a group of proteins, such as prolamins and glutelins,  stored with starch in the endosperm of various cereal grass grains. As of [update], gluten-related disorders were increasing in frequency in different geographic areas. The increase might be explained by the popularity of the Western diet, the expanded reach of the Mediterranean diet which also includes grains with gluten, the growing replacement of rice by wheat in many countries,  the development in recent years of new types of wheat with a higher amount of cytotoxic gluten peptides,  and the higher content of gluten in bread and bakery products, due to the reduction of dough fermentation time. At the protein level, we found no evidence to support an increased immunostimulatory potential of modern winter wheat. The following classification of gluten-related disorders was announced in by a panel of experts in London, and published in February  . Autoimmune conditions related to gluten include celiac disease, dermatitis herpetiformis, and gluten ataxia. There is research showing that in people with gluten ataxia early diagnosis and treatment with a gluten-free diet can improve ataxia and prevent its progression. Coeliac disease American English : celiac CD is one of the most common chronic, immune-mediated disorders, triggered by the eating of gluten, a mixture of proteins found in wheat, barley, rye, and oats and derivatives.
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