It’s often used to treat depression, and also sometimes panic attacks, obsessive compulsive disorder OCD and post-traumatic stress disorder PTSD. Sertraline helps many people recover from depression, and has fewer unwanted side effects than older antidepressants. If you have diabetes, sertraline can make it more difficult to keep your blood sugar stable. Monitor your blood sugar more often for the first few weeks of treatment with sertraline and adjust your diabetes treatment if necessary. The usual dose of sertraline is 50mg a day in adults. But it might be started at a lower dose, then increased gradually to a maximum dose of mg a day. If you have liver problems, your doctor might give you a lower dose or advise you to take sertraline less often. The usual dose of sertraline in children aged 6 to 12 is 25mg a day, but this may be increased to 50mg a day after a week. The usual dose of sertraline in children aged 13 to 17 is 50mg a day.
Results of this study are compelling due to the use of a clinically translational nonhuman primate model allowing for placebo-controlled, longitudinal, randomized study design. Alterations in glucose and lipids could be due to effects of the drug on body weight, body composition, or behavior. Female cynomolgus monkeys are uniquely well-suited for this study because, in addition to being a useful and well-characterized model of depression Shively and Willard, ; Willard and Shively, , they are also an established model of diet-induced obesity Mubiru et al.
You should not use sertraline if you are allergic to it, or if you also take pimozide. HOMA-IR correlates with euglycemic glucose clamp results, the reference method for assessing insulin sensitivity, in both humans Bonora et al. Behavior was recorded during 10 minute focal animal observations, 6—8 times per month, counterbalanced for time of day, for 12 months during both the Pretreatment and Treatment Phases an average of Plasma concentrations of sertraline and metabolite desmethylsertraline demonstrated the drug was successfully delivered via oral dosing, producing plasma concentrations similar to those measured in patients Reis et al. SEA monitored the diet, provided veterinary expertise, performed the iliac artery biopsies, and contributed to data interpretation. Ask your doctor before taking a nonsteroidal anti-inflammatory drug NSAID for pain, arthritis, fever, or swelling. Maintain your normal eating habits.
Selective serotonin reuptake inhibitor SSRI antidepressants are widely prescribed for depression and other disorders. Acute effects on body composition and carbohydrate metabolism have been reported, but little is known regarding the effects of chronic SSRI use. Over the 18 month treatment period, the placebo group experienced increases in body weight, body fat visceral and subcutaneous fasting insulin concentrations, and homeostasis model assessment of insulin resistance scores HOMA-IR. Sertraline treatment altered adiponectin in an unusual way — reducing circulating adiponectin in depressed monkeys without affecting fat mass or body weight. Deleterious effects on adiponectin, a potentially insulin-sensitizing and atheroprotective protein, may result in adverse effects on cardiovascular health despite otherwise beneficial effects on body composition and carbohydrate metabolism. Obesity, diabetes mellitus, and metabolic syndrome are all major risk factors for cardiovascular disease CVD and stroke. In more than two-thirds of Americans were overweight, and one-third of adults were classified as obese according the criteria set forth by the American Heart Association National Center for Health Statistics, This increasing prevalence of obesity, particularly visceral obesity, is most likely also driving an increased incidence of insulin resistance and type 2 diabetes mellitus Despres and Lemieux,